Find focus, mental clarity, and calm with help from our Lion's Mane (Hericium erinaceus) mycelium-based supplements. Known as "the Smart Mushroom", Lion's Mane is ideal for anyone seeking cognition, memory, and mood support. And as an added bonus, Lion's Mane is also well-known for supporting the nervous system.*

Supports Cognitive Health, Focus, Memory, and Creativity          

Supports Heart Health and Blood Flow

Supports Emotional Resilience Against Stress and Anxiety

Supports Brain Health with Powerful Antioxidants



Supports Longevity through Superior Antioxidant Health*

Supports Lower Systemic Inflammation*

Supports Adaptogenic Benefits to Alleviate Stress in Body*

Supports Balanced and Robust Immunity *


Supports Maximum Immune Health with Proven Mushroom Blend*

Supports Balanced Inflammation Response*

Supports Anti-Oxidant Protection for the Body*

Supports Increased Blood and Cellular Detox*


Supports Overall Wellness With Synergistic Super Blend*

Supports Calmness*

Supports Energy*

Supports Immune System*

Mushroom Health Benefits Beyond Simple Nutrition

One of the fastest-rising supplement categories today is mushrooms. Traditional Chinese practices have used mushrooms for thousands of years to treat various ailments, detoxify the body, and provide overall well-being and longevity.*1

Mushrooms: What Are They All About?

Natural mushrooms are loaded with polysaccharides, antioxidants, amino acids, polyphenols, and digestive enzymes. Most of the scientific research related to mushrooms is focused on a specific type of soluble fiber found in the fungi cell walls called beta-glucans (β-glucan). Researchers have discovered that beta-glucans offer a wide range of health benefits from support for the immune system, protection against brain degeneration, and even reduced stress.*2-5


Free Shipping

All orders over $99

Limited Time


Risk free

Free returns within 30 days


At Dose of Nature, we firmly believe in the power of 9. For years, we have utilized 9 key mushrooms to assist professional athletes, business professionals, and individuals who are both healthy and ill. Our primary objective has always been to aid those who require assistance. We offer the most advanced and purest mushroom extracts available on the market, with the aim of providing individuals with an advantage over their competitors, restoring their health and wellness, and assisting those who lead a fast-paced and exhausting daily lifestyle.

We’ve developed a patent-pending process for a multi-stage, alcohol-free, 4X cold extraction process that maximizes the extraction of all the bioactive nutrients. We never compromise on mushroom quality, utilizing only the mushroom fruiting body as nature intended. Trust in Nature. Dose of Nature.

3 Key Steps In Identifying A Quality Mushroom Supplement

We spent years researching mushroom supplements. There are specific aspects that differentiate high-quality mushroom supplements from generic ones. Below are the three most essential steps to consider before deciding which mushroom brand is best for your needs.


Before purchasing any mushroom supplement, be sure to look at the supplement facts section of the label, which will indicate the type of mushrooms used and if they are in an extract or powder form, also if they were exposed to heat;. Dose of Nature only uses extracts and not powders and we never use heat in our patent pending NuXtrax™ process to have the highest potency and deliver better results. NuXtrax™ offers a distinct advantage over powders as it allows for better absorption of extracts by the body. Unlike powders that contain chitin, an indigestible fiber that is excreted as waste, NuXtrax™ ensures that vital beta-glucans are not lost during the digestive process. Most labels will indicate how potent an extract is by displaying the concentration in the form of a ratio, such as “4:1 Extract 100 mg,” which is equivalent to 400 mg (4 x 100 mg) of dried mushroom powder.


If you want to achieve optimal results, it is important to select a supplement that has both the correct mushrooms and the proper dosages. For Lion’s Mane, recognized for enhancing cognitive performance, we recommend a daily dosage of at least 750 mg in “extract form” or 3,000 mg in powder form. For the other top mushrooms on our list, look for a formula that contains each of them individually in a daily dosage of at least 80 mg in “extract form” or 320 mg in powder form.


Always choose a supplement that has next to each mushroom’s name, the words “fruiting body.” Avoid mushroom supplements with “myceliated grain” in the ingredients or some variation of the word “mycelium.” Dose of nature only uses “fruiting body” in all our NuXtrax™ extractions.

The fruiting body is the actual mushroom cap and stem. Mycelium is the root system of a mushroom grown on top of a grain substrate resulting in a supplement that is about 50% roots, 50% filler, and 0% of real mushroom. Why would some manufacturers do this? Because mycelium is cheaper and faster to produce than waiting for a full proper mushroom to grow. The problem is that the fruiting body is where most of the beta-glucans, the beneficial compounds of a mushroom, are found. A 2014 study published in the journal Microbiology analyzed the concentration of beta-glucans in both fruiting bodies and mycelia. The study concluded that fruiting bodies have up to 100% more beta-glucansthan mushrooms grown on a mycelium base.16 This study lends further support to a separate 2011 study published in the journal Food Chemistry which indicated that fruiting bodies have as much as 2.5 times the amount of beta-glucans than mycelia.17 To achieve peak results, we recommend selecting a supplement that uses only fruiting bodies.




  1. Aung, Steven Kh. 2005. “The Clinical Use Of Mushrooms From A Traditional Chinese Medical Perspective”. International Journal Of Medicinal Mushrooms, 375-376. doi:10.1615/intjmedmushrooms.v7.i3.290
  2. D, Akramiene, Kondrotas A, Didziapetriene J, and Kevelaitis E. 2007. “Effects Of Beta-glucans On The Immune System”. Medicina (Kaunas, Lithuania) 43 (8).
  3. Daou, Cheickna, and Hui Zhang. 2012. “Oat Beta-glucans: Its Role In Health Promotion And Prevention Of Diseases”. Comprehensive Reviews In Food Science And Food Safety 11 (4): 355-365. doi:10.1111/j.1541-4337.2012.00189.x.
  4. HONG, HEEOK, CHANG-JU KIM, JAE-DEUNG KIM, and JIN-HEE SEO. 2014. “Β-Glucan Reduces Exercise-Induced Stress Through Downregulation Of C-Fos And C-Jun Expression In The Brains Of Exhausted Rats”. Molecular Medicine Reports 9 (5): 1660-1666. doi:10.3892/mmr.2014.2005.
  5. Sabaratnam, Vikineswary, Wong Kah-Hui, Murali Naidu, and Pamela Rosie David. 2013. “Neuronal Health – Can Culinary And Medicinal Mushrooms Help?”. Journal Of Traditional And Complementary Medicine 3 (1): 62-68. doi:10.4103/2225-4110.106549.
  6. Sabaratnam, Vikineswary, Wong Kah-Hui, Murali Naidu, and Pamela Rosie David. 2013. “Neuronal Health – Can Culinary And Medicinal Mushrooms Help?”. Journal Of Traditional And Complementary Medicine 3 (1): 62-68. doi:10.4103/2225-4110.106549.
  7. Lai, Puei-Lene, Murali Naidu, Vikineswary Sabaratnam, Kah-Hui Wong, Rosie Pamela David, Umah Rani Kuppusamy, Noorlidah Abdullah, and Sri Nurestri A. Malek. 2013. “Neurotrophic Properties Of The Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Higher Basidiomycetes) From Malaysia”. International Journal Of Medicinal Mushrooms 15 (6): 539-554. Begell House. doi:10.1615/intjmedmushr.v15.i6.30.
  8. Mori, K. et al. (2011) “Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice”, Biomedical Research, 32(1), pp. 67-72. doi: 10.2220/biomedres.32.67.
  9. Lai, P. et al. (2013) “Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia”, International Journal of Medicinal Mushrooms, 15(6), pp. 539-554. doi: 10.1615/intjmedmushr.v15.i6.30.
  10. D, A. et al. (2007) “Effects of Beta-glucans on the Immune System”, Medicina (Kaunas, Lithuania), 43(8), p. Available at:,growth%20in%20promotion%20stage%20too. (Accessed: 30 June 2020).
  11. Elsayed, E. et al. (2014) “Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications”, Mediators of Inflammation, 2014, pp. 1-15. doi: 10.1155/2014/805841.
  12. Vitak, T. et al. (2017) “Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus”, World Journal of Diabetes, 8(5), p. 187. doi: 10.4239/wjd.v8.i5.187.
  13. Wong, K. et al. (2011) “Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal MushroomHericium erinaceus(Bull.: Fr) Pers. (Aphyllophoromycetideae)”, Evidence-Based Complementary and Alternative Medicine, 2011, pp. 1-10. doi: 10.1093/ecam/neq062.
  14. Geng, P. et al. (2017) “Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms”, BioMed Research International, 2017, pp. 1-16. doi: 10.1155/2017/9648496.
  15. Socala, K. et al. (2015) “Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice”, International Journal of Medicinal Mushrooms, 17(3), pp. 209-218. doi: 10.1615/intjmedmushrooms.v17.i3.10.
  16. Bak, Won Chull, Ji Heon Park, Young Ae Park, and Kang Hyeon Ka. 2014. “Determination Of Glucan Contents In The Fruiting Bodies And Mycelia Of Lentinula Edodes Cultivars”. Mycobiology 42 (3): 301-304. doi:10.5941/myco.2014.42.3.301.
  17. Nitschke, Jörg, Hendrik Modick, Ekkehard Busch, Reimund Wantoch von Rekowski, Hans-Josef Altenbach, and Helga Mölleken. 2011. “A New Colorimetric Method To Quantify Β-1,3-1,6-Glucans In Comparison With Total Β-1,3-Glucans In Edible Mushrooms”. Food Chemistry 127 (2): 791-796. doi:10.1016/j.foodchem.2010.12.149.

*FDA Warning: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.